Reduced IgG galactosylation signifies various conditions, including inflammatory diseases (rheumatoid arthritis, systemic lupus erythematosus, Crohn’s disease, and nonalcoholic fatty liver disease), infections (Mycobacterium tuberculosis, HIV+, and HCV+), cancers (prostate cancer, gastric cancer), and aging, potentially influenced by IL-6 [26]. This evidence concerns the gene IL6 and Crohn disease.