GHD has been detected in roughly 30% of chronic heart failure patients and GHD patients show impaired functional capacity and LV modelling and elevated serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in comparison with GH sufficient patients [193]. GH replacement in AGHD patients improves systolic function [194]. This evidence concerns the gene GH1 and congestive heart failure.