CYP27B1 and melanoma: Accordingly, vitamin D receptor (VDR), as well as CYP27B1, are more under-expressed in highly pigmented melanomas than in AHMs [11,40,41,42]; as reported in the literature, all these aspects can justify the better survival rates (disease-free survival and overall survival) observed in amelanotic melanomas compared to pigmented melanomas [39,43,44].