When further subgroup analysis was performed with respect to age ≤75 years (43 patients in sinus rhythm and 27 patients with AF), we observed statistically significantly higher values of NT-proBNP, IL-6 and IL-6/IL-10 ratio in patients with AF in comparison to patients in sinus rhythm (Table 2, Figure 2). This evidence concerns the gene NPPB and atrial fibrillation.