Therefore, GBM is defined as an IDH-wildtype adult-type diffuse glioma that exhibits necrosis and microvascular proliferation, with EGFR amplification, mutation of TERT promoter, or gain of chromosome 7 (+7) and loss of chromosome 10 (−10), and the new term is “GBM IDH-wildtype CNS WHO grade 4” [29]. The gene discussed is EGFR; the disease is glioblastoma.