It has been declared that hyperglycemia reduces the mRNA expressions of IBSP, LRP5, OCN OPN, OSN, OSP, and RUNX2, increases the mRNA expression of RANKL, and does not change the expression of BMP-2, BMP-7, and DKK1 level in craniomandibular bone samples of young rats feeding on a high-fructose corn syrup diet [11]. This evidence concerns the gene SPP1 and Hyperglycemia.