Levels of S-1-P produced by downregulated acid ceramidase induce the loss of E-cadherin in melanoma cells, along with an increase in gangliosides, promoting epithelial–mesenchymal transition (EMT) processes and adhesion to the extracellular matrix, which characterizes the aggressive phenotype of melanoma [60,61,62]. The gene discussed is CDH1; the disease is melanoma.