Regarding the number of PDE4B-positive cells in lamina propria, a statistically significant difference was observed between control and all CRC Dukes’ stages, as well as CRC stage Dukes’ A and CRC stage Dukes’ B, C, and D. Additionally, CRC stage Dukes’ C had significantly more PDE4B-positive cells in the lamina propria than in the CRC stage Dukes’ B (Figure 2f). Here, PDE4B is linked to colorectal carcinoma.