The first category includes tissues affected in an isolated manner such as striated muscle, peripheral muscle, and adipose tissue, e.g., lipodystrophy and familial partial lipodystrophy of the Dunnigan type (FPLD), which is caused due to a heterozygous mutation LMNA gene [27,28,40,41]. The gene discussed is LMNA; the disease is familial partial lipodystrophy.