In considering a possible origin for the IFN and IP-10/CXCL10 abnormalities in the NPC brain, we have suggested that the widespread presence of DAMPs, excessive generation of ROS, and lipid peroxidation, which are prominent in NPC, could be triggering sterile inflammatory patterns through NF-κB and Toll-like-receptor signaling pathways [11]. The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.