ACLY and type 2 diabetes mellitus: In our primary MR analyses, we found that genetically predicted ACLY inhibition was associated with a lower waist-to-hip ratio (β = −1.17 per standard deviation lower LDL-c, 95% confidence intervals (CI)= −1.61 to −0.73), p < 0.001) but not with risk of T2DM (odds ratio (OR): 0.74, 95% confidence interval: 0.25 to 2.19, p = 0.593) (Table S1).