In contrast, genetically predicted HMGCR inhibition was associated with a higher waist-to-hip ratio (β = 0.15; 95%CI = 0.04 to 0.26; p = 0.008) and T2DM risk (OR = 1.73, 95% CI = 1.27 to 2.36, p < 0.001). This evidence concerns the gene HMGCR and type 2 diabetes mellitus.