The altered gene expression of Bgl-Drosha, Bgl-DGCR8, Bgl-Ran, Bgl-Exp5, Bgl-Dcr, and Bgl-Ago2, as revealed via our RNA-Seq analyses (Figure 1), together with localization of the Bgl-Ago2 protein to the sporocysts that formed in the B. glabrata intestinal digestive gland 20 days post exposure to S. mansoni miracidia (Figure 2), strongly inferred that the miRNA pathway plays a central role in the molecular response of B. glabrata to its infection by the S. mansoni parasite. The gene discussed is XPO5; the disease is infection.