Its role has been demonstrated in different SHP2-mutated animal models, which show cardiac phenotypes such as Xenopus [16], Zebrafish [17], and several mouse models of NS (Ptpn11D61G/+ mice), showing enlarged cushions, ASD, VSD, double-outlet right ventricle (DORV), myocardial thinning with no evidence of HCM [18], and LS mutants (Q510E-Shp2 mice), showing HCM and enlarged atria [19]. The gene discussed is PTPN11; the disease is ventricular septal defect.