MAP2K7 and cardiac hypertrophy: The main molecular signaling event involved in the pathogenesis of cardiac hypertrophy is the activation of the Ras/Raf/MEK/MAPK pathway and the downstream molecular cascades, the ERK and the Calcineurin/NFAT pathways, with consequent modulation of specific transcription factors such as MEF2, JUN, and GATA4, which produce the expression of genes involved in the pathogenesis of hypertrophy.