AKT1 and colonic neoplasm: Interestingly, miR-451a was downregulated in MSS/EMAST-S and MSS/EMAST-H but not MSI-H/EMAST-H tumors, which might have a certain prognostic significance since it was shown that miR-451a can inhibit colon cancer growth through the downregulation of the P13K/AKT pathway [54].