Additionally, a variant in the epilepsy- and thrombopoiesis-associated gene DIAPH1 was also identified in our digenic network, but it was not a core gene in our digenic network (gene centrality score was far less than SCN1A and MYH9, details in Supplementary Table S2) and the patient’s variant in DIAPH1 was classified as uncertain according to the ACMG guideline. This evidence concerns the gene SCN1A and epilepsy.