SCN1A and epilepsy: Similarly, although the Digenic Effect predictor predicted our digenic combination effects into a monogenic plus modifier model, we can only speculate that the modifier effect of MYH9 may be the reason for the intra-familial variability of phenotype; however, other genetic and environmental factors may also attribute to the severity variability of epilepsy within the family, so more experimental studies are also needed to analyze the functional interaction of MYH9 and SCN1A to support the modifier effect of MYH9 in our network.