CTNNB1 and colorectal cancer: In a study conducted by Vasovcak et al. in 2011 [16], which involved 103 tumors from 102 colorectal cancer patients, two mutations in CTNNB1 were identified: p.Ser45Phe, a well-known pathogenic variant, and p.Ala20Ser, which the authors concluded was likely not associated with the disease.