KSR2 and obesity due to melanocortin 4 receptor deficiency: To the best of our knowledge, our study is the first to report these variants in the KSR2 gene (c.1765-8G>A, c.1673G>A, c.1057G>A, and c.923T>C), classified as VUSs, in association with early-onset obesity in the Arab population, specifically from Qatar and Saudi Arabia.