NF2 gene mutation is associated with the early development of meningiomas [89,90,91] and is recognized as the most common gene mutation in cases of atypical meningiomas (Table 2), present in up to 75% of tumors, making a meningioma 3.78 times more likely to be atypical than without an NF2 gene alteration [68,80,92]. This evidence concerns the gene NF2 and meningioma.