Mutations in the genes AKT1, SMARCB1, and SMO (Table 2) are rare in cases of atypical meningiomas, and mutations in the genes KLF4 and TRAF7 are associated with an indolent clinical behavior, thus making these meningiomas have a low risk of progression [54,68,80,81,82]. This evidence concerns the gene KLF4 and meningioma.