In this study, we found that low levels of adropin (<3.5 ng/mL) in individuals with T2DM and known adverse cardiac remodeling significantly increased the predictive ability of NT-proBNP for asymptomatic HFpEF in the presence of near-normal levels of NT-proBNP (<125 pmol/L). This evidence concerns the gene NPPB and type 2 diabetes mellitus.