NPPB and chronic kidney disease: However, regardless of any differences in age, body composition, and the comorbidity profile (CAD, LVH, atrial fibrillation, and chronic kidney disease), elevated levels of NT-proBNP (>3000 pg/mL) retained their ability to predict all-cause mortality and cardiovascular death in patients with both HFpEF and HFrEF [40,41].