In our previous work in patients with liver cancer, FVIIa–AT levels but not EV-associated TF-dependent procoagulant activity predicted the risk of overall mortality and no correlation was found between FVIIa–AT levels and EV-associated TF-dependent procoagulant activity, thus suggesting that, in this study population, TF-positive EVs were not the main source of TF–FVIIa interaction [41]. The gene discussed is TF; the disease is liver cancer.