HER2 (2+ and 3+) positive scores were more commonly detected among RCC patients than in LCC patients (62.5% and 75% vs. 37.5% and 25%, respectively), while HER2 (1+) score was more prevalent in LCC patients than in RCC patients (76.9% vs. 23.11%). The gene discussed is ERBB2; the disease is leukoencephalopathy with calcifications and cysts.