A total of 25 genes (8.77%) from the 285 COI-enriched candidates were identified as having associations with various cardiomyopathy subtypes, including hypertrophic, dilated, and arrhythmogenic cardiomyopathy (e.g., DSC2 (9% of COIs; FDR-adjusted p-value = 8.2 × 10−6), DSG2 (10% of COIs; FDR-adjusted p-value = 1.6 × 10−10), DSP (15% of COIs; FDR-adjusted p-value = 9.2 × 10−101), MYL2 (9.4% of COIs; FDR-adjusted p-value = 8.5 × 10−3), PKP2 (8.7% of COIs; FDR-adjusted p-value = 1.6 × 10−5), and JUP (12% of COIs; FDR-adjusted p-value = 3 × 10−13)). Here, DSC2 is linked to cardiomyopathy.