Alternatively, genes with no reported COI are enriched in gene sets associated with germ cell development and implicated in infertility mainly caused by spermatogenic failure (e.g., CATIP, CFAP65, CEP19) and oocyte/zygote/embryo maturation arrest (e.g., PADI6, REC114, WEE2). This evidence concerns the gene PADI6 and Infertility.