Moreover, the generated list of proteins included several known biomarker candidates implicated with both the initiation and the progression of CLL, such as FAM50A [70], IKZF3 [71], KRAS [72], MAP2K1 [73], SAMHD1 [74], and SF3B1 [75]. This evidence concerns the gene SF3B1 and B-cell chronic lymphocytic leukemia.