SHANK3 and 22q11.2 deletion syndrome: For instance, gene DSCAM is involved in contributing to nervous system in schizophrenia with 22q11.2 deletion syndrome [24]; SHANK3 is a known autism gene and mutations in this gene also appear in the schizophrenia phenotype [25]; the ZMYND11 gene is implicated in complex neuropsychiatric features [26]; ANK2 is essential for neuronal morphogenesis and long term memory in drosophila studies [27].