CST3 and cystic fibrosis: At the metabolic level, a longitudinal study performed in a population of 7769 individuals included in the Doetinchem Cohort Study [44] evidenced that markers such as high-density lipoproteins, triglycerides, alanine aminotransferase, gamma-glutamyltransferase, albumin, uric acid, cystatin C, and creatinine were not predictive of CF.