In pancreatic ductal adenocarcinoma (PDAC) cells, for example, SIRT5 catalyzes the deacetylation of aspartate transaminase 1 (GOT1) at specific lysine residues, thereby inhibiting its enzymatic activity and suppressing the glutamine–glutathione metabolic pathway. The gene discussed is GOT1; the disease is pancreatic ductal adenocarcinoma.