Notably, in experimental models of MS, and specifically in knock-out mice for the gene of IL-5, antigen-specific T-cells promoted the release of IFN-gamma and TNF-alfa, in the absence of anti-inflammatory cytokines such as IL-4 or IL-10, indicating a predominant Th1 environment following immunization [17]. The gene discussed is IL5; the disease is myeloid sarcoma.