For example, the consumption of a high-fat diet increases the abundance of sulfate-reducing bacteria [400], which leads to elevated sulfide concentrations and might reduce disulfide bonding in mucus, cleaving the network of polymeric proteins secreted by cuprocytes known as MUC2 (oligomucous mucus gel-forming) [401], leading to defects in the mucus layer and an increase in intestinal inflammation [401], colitis scores [401], and IBD [402]. Here, MUC2 is linked to colitis.