Macia L reported that in some animal experimental models, such as the DSS-induced Gpr43−/−, GPR109a−/− mouse colitis, and AOM/DSS-induced GPR176−/− mouse CRC models, the deletion of GPR accelerated the development of colonic inflammation and colorectal cancer [42,43,44]. The gene discussed is FFAR2; the disease is colorectal carcinoma.