Butyrate has also been shown to induce apoptosis through the activation of G protein-coupled receptor 43 (GPR43), which is frequently lost in colon cancer cells and is usually accompanied by the silencing of its genes encoding various receptors and transporter proteins involved in butyric acid-induced apoptosis in CRC cell lines [27,28]. The gene discussed is FFAR2; the disease is malignant colon neoplasm.