DLG4 and Cognitive impairment: Although further measurements of synaptic indicators such as PSD-95 and synaptophysin will be important for illustrating synaptic repair and will be conducted in future studies, the LTP data described above suggest that FK506 may not only mitigate TauO-associated cognitive impairments but also contribute to the restoration of normal synaptic function, providing further evidence for the therapeutic potential of CaN inhibition in the context of AD pathology.