The triple transgenic (3xTg) AD mice are one of the most widely used AD models due to their unique ability to recapitulate both Aβ and Tau pathology [60] through the expression of APP695 (Swedish) and M146V PSEN1 transgenes combined with the expression of the human Tau MAPT (P301L) transgene [60,61]. This evidence concerns the gene MAPT and Alzheimer disease.