Strikingly, the chemical induction of Hsp70 using ML346 (10 μM) resulted in opposite effects on autophagy since a reduction in LC3 I/II conversion was observed while p62 was accumulated (Figure 1E,F), suggesting a differential regulation of autophagy following the overactivation of PSR and Hsp70 by the exposure to heat shock or by the chemical inducer ML346 in NSCLC cells. This evidence concerns the gene HSPA1A and non-small cell lung carcinoma.