MAP1LC3A and non-small cell lung carcinoma: Strikingly, the chemical induction of Hsp70 using ML346 (10 μM) resulted in opposite effects on autophagy since a reduction in LC3 I/II conversion was observed while p62 was accumulated (Figure 1E,F), suggesting a differential regulation of autophagy following the overactivation of PSR and Hsp70 by the exposure to heat shock or by the chemical inducer ML346 in NSCLC cells.