To this end, treating A549 tumor cells with cisplatin, a standard first-line chemotherapy agent for lung cancer, alone or in combination with VER-155008, promoted the transcriptional upregulation of both Hsp70 and autophagy-related genes, ULK1, ATG7, and p62 (Figure S5), suggesting the upregulation of autophagy and Hsp70 to confront cisplatin cytotoxicity [30,37]. Here, HSPA1A is linked to lung cancer.