Interestingly, the very recent study of Ferretti et al. has demonstrated similar findings in pancreatic cancer, whereby Hsp70 inhibition resulted in the activation of AMPK–Beclin1-mediated autophagy, while the combined inhibition of Hsp70 and autophagy exerted synergetic effects on pancreatic tumor cell viability, both in vitro and in vivo [59]. This evidence concerns the gene HSPA1A and familial pancreatic carcinoma.