It was found in maternal plasma as an early predictor of preeclampsia (PE) at an early gestational age because it was demonstrated that it is involved in the regulation of trophoblast cell migration and invasion, and the dysregulation of these processes may promote the development of PE [48] through the activation of Wnt signaling, PI3K/AKT signaling, and focal adhesion molecule signaling activated by integrin clustering and providing the reorganization of actin cytoskeleton [48]. This evidence concerns the gene AKT1 and preeclampsia.