PRRT2 and Alzheimer disease: Calycosin’s protective effects, including improved cognitive ability and anti-oxidative and anti-inflammatory effects, were mediated through the activation of the protein kinase C (PKC) pathway, disrupted by a PKC inhibitor, calphostin C. This suggests that Calycosin mitigates oxidative stress and inflammatory responses in the hippocampus of AD model mice, leading to improved cognitive function [60].