Infection by SARS-CoV-2 also interferes with anti-oxidant pathways such as nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor, which controls expression of genes that protect against cellular stress, indirectly resulting in increased intra- and extracellular oxidative stress and overall systemic inflammation [167]. This evidence concerns the gene NFE2L2 and infection.