CLH2 expression influenced tumor size (≤2 cms vs. >2 cms), and EC-45M1 detection influenced NAT and association with premalignant lesions (AwPml) such as intraductal papillary mucinous neoplasms (IPMN) and pancreatic intraepithelial neoplasia (PanIN). The gene discussed is BRD2; the disease is pancreatic intraductal papillary-mucinous neoplasm.