HMGB1 and Wilson disease: It is worth mentioning here that the production of HMGB1 in WD may be related not only to the up regulation of p65, but HMGB1 secretion may be stimulated through many factors, including those that may be important from the point of view of the mechanism of tissue damage in WD, such as oxidative stress, inflammation, apoptosis, necroptosis, cuproptosis, and ferroptosis.