In the early stage of AD progression, Western blot (WB) data showed no statistically significant difference in the protein expression of the FBLN1 gene in the hippocampal tissue of 7-month-old female DKO mice compared to same-age and same-sex CBAC57 mice (p > 0.05), as shown in Figure 8A and Table S7. The gene discussed is FBLN1; the disease is Alzheimer disease.