BRCA1 and ovarian carcinoma: In BRCA1/2-deficient models in breast and ovarian cancer, PARPi increased cytosolic DNA and activated cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) signalling, and upregulated pro-inflammatory chemokines such as CCL5 and CXCL10 [67,68,69].