NFKB1 and colorectal carcinoma: For example, the administration of low doses of epoxyketooctadecenoic acid (EKODE) has been found to exacerbate intestinal barrier dysfunction, lipopolysaccharide, and bacterial translocation along with CRC development via inflammatory signaling pathways such as NF-κB and c-Jun N-terminal kinases (JNK) [36].