For example, Lactobacillus fermentum supplementation in Dextran Sulfate Sodium (DSS)-induced colorectal cancer rodent models attenuated NF-κB signaling pathway signaling by decreasing key proteins IκBα and p65 and target protein cyclooxygenase-2, a known pro-oxidant [262]. The gene discussed is NFKB1; the disease is colorectal cancer.