FLT1 and endothelial dysfunction: The ischemic placenta releases anti-angiogenic and inflammatory factors such as sFlt-1 (soluble fms-like tyrosine kinase 1, a soluble form of vascular endothelial growth factor receptor 1) into the maternal circulation, causing maternal endothelial dysfunction and clinical manifestations of preeclampsia: hypertension, proteinuria, and end-organ damage [27].