ALB and preeclampsia: Importantly, HFD-fed Asb4−/− dams had higher blood pressure and urinary albumin excretion than NC-fed Asb4−/− dams while HFD-fed Asb4−/− dams had a decreased number of surviving fetuses compared to NC-fed Asb4−/− dams at the term (e.g., 18.5 days post coitus), suggesting that all the preeclampsia-like phenotypes presented in Asb4−/− dams were aggravated by HFD-induced obesity (Table 1).