Specifically, PTX-3 was found to be higher in patients with more severe sepsis (standard mean difference = 18.5 ng/mL; standard error: 4.5 ng/mL, p < 0.0001) and non-survivors (standard mean difference = 40.3 ng/mL; standard error: 6.8 ng/mL, p < 0.0001), with an increased risk of mortality by 91% (hazard ratio: 1.91, 95% CI: 1.53 to 2.46, p < 0.0001) [94]. The gene discussed is PTX3; the disease is Sepsis.