PNPLA2 and obesity due to melanocortin 4 receptor deficiency: When investigating the relationship between the expression of the two lipolytic enzymes and AQP7 across the different depots, a positive correlation was found between the protein expression of ATGL and AQP7 in both women with normal weight (p = 0.003, r = 0.630) and with upper-body obesity (r = 0.570, p = 0.004) (Figure 5A,B).