Zhang et al. screened a Chinese cohort of 1886 patients with LN by whole-exome sequencing and identified only a small fraction of patients with pathogenic gene variants, primarily related to NF-kB, type I interferon (IFN-I), PI3K/AKT, JAK/STAT, RAS/MAPK and complement pathways [38]. The gene discussed is SOAT1; the disease is lobular neoplasia.