ENO1 and lobular neoplasia: These Authors underline the weak link between anti-double stranded DNA (anti-dsDNA) and renal pathology and argue that circulating levels of anti-enolase 1 (anti-ENO1) and anti-histone 2 (anti-H2) IgG2 better characterize patients with LN vs. those with non-renal SLE and decrease after IS therapy [60].