In this session, we will discuss the construct validity of rodent models of PD that simulate its three main pathological features: (i) chronic progressive neurodegeneration of the dopaminergic neurons of the SNpc, (ii) presence of protein aggregates containing a-synuclein, simulating Lewy bodies, and (iii) mutations of PD-related genes: SNCA, Parkin, Pink-1, and DJ-1. The gene discussed is PRKN; the disease is Parkinson disease.