It has been found that the stimulation of EMT by MDSCs additionally relies on the effect of IL-6 secretion, which activates the Janus kinase (Jak)/signal transducer and activator of transcription (STAT) pathway, as well as nitric oxide (NO), inducing Notch signaling in BC cells along with the maintenance of STAT activation [50]. The gene discussed is SOAT1; the disease is breast cancer.