CDH1 and neoplasm: Tumor mutational burden (TMB) was not significantly different between the CDH1-altered and -unaltered groups (p = 0.05); 84.1% of the CDH1-altered group had a low TMB and 15.9% had a high TMB, whereas 88.3% of the CDH1-unaltered group had a low TMB and 11.7% had a high TMB (Table 2).