CDH1 and metastatic malignant neoplasm in the lymph nodes: With respect to the prognostic value of reduced E-cadherin levels in breast cancer, previous studies found that these promoted tumor invasion and metastasis [3,21]; as a result, overall survival and disease-free survival duration were significantly shorter and correlated with tumor histological grade, TNM stage, tumor size, and the presence of lymph node metastasis [22,23,24].