ACADVL and early-onset autosomal dominant Alzheimer disease: Interestingly, while impaired mitochondrial function resulting from VLCAD dysfunction could lead to decreased energy production and increased oxidative stress (hallmarks of Alzheimer’s pathology), studies have indicated an upregulation of VLCAD (ACADVL) in glial cells, correlating with beta-amyloid protein accumulation in Alzheimer’s disease [37].