GNRH1 and adenomyosis: The current medical treatments for symptomatic adenomyosis, including nonsteroidal anti-inflammatory drugs (NSAIDs), progestins, oral contraceptives, a levonorgestrel-releasing intrauterine system (LNG-IUS), as well as both gonadotropin-releasing hormone (GnRH) agonists and antagonists, are based on anti-proliferative and anti-inflammatory effects by controlling the hormonal medium.