SYNJ1 and Parkinson disease: Recently, we investigated the role of SYNJ1 in the pathogenesis of PD in relation to αSyn aggregation and found that SYNJ1 deficiency causes the accumulation of phosphatidylinositol-3,4,5-trisphosphate (PIP3), which directly interacts with αSyn and accelerates the formation of αSyn fibrils.