PTEN and cancer: They are intervein in important cancer signaling pathways, including Wnt/β-catenin signaling, mitogen-activated protein kinase (MAPK)/Extracellular regulated-kinase (ERK) and Phosphatase and Tensin Homolog (PTEN)/Phosphatidylinositol-4,5-Bisphosphate 3-Kinase (PIK3)/AKT Serine/Threonine Kinase 1 pathways, p53, and K-Ras [1,2,3,4,5].