STAT5A signaling [129], CSPG4 [130], MMP-1 [131], MMP-3 [132], MMP-8 [133], MMP-9 [134], and LUM [135] are all involved in cancer cell migration, invasion, and metastasis, while PKM supports the growth and survival of cancer cells by favoring aerobic glycolysis [136]. The gene discussed is MMP8; the disease is cancer.